leukemoid reactions การใช้

• CML must be distinguished from a leukemoid reaction, which can have a similar appearance on a blood smear.
• Serum leukocyte alkaline phosphatase is normal or elevated in leukemoid reaction, but is depressed in chronic myelogenous leukemia.
• The bone marrow in a leukemoid reaction, if examined, may be hypercellular but is otherwise typically unremarkable.
• Historically, various clues including the leukocyte alkaline phosphatase score and the presence of basophilia were used to distinguish CML from a leukemoid reaction.
• Conventionally, a leukocytosis exceeding 50, 000 WBC / mm 3 with a significant increase in early neutrophil precursors is referred to as a leukemoid reaction.
• However, leukemoid reactions can resemble more serious conditions such as chronic myelogenous leukemia ( CML ), which can present with identical findings on peripheral blood smear.
• Leukemoid reactions are generally benign and are not dangerous in and of themselves, although they are often a response to a significant disease state ( see " Causes " below ).
• A leukocyte count above 25 to 30 x 10 9 / L is termed a " leukemoid reaction ", which is the reaction of a healthy bone marrow to extreme stress, trauma, or infection.
• The morphologic changes have also been described in myxedema associated with panhypopituitarism, vitamin B12 and folate deficiency, multiple myeloma, enteroviral infections, malaria, muscular dystrophy, leukemoid reaction secondary to metastases to the bone marrow, and drug sensitivity, sulfa and valproate toxicities are examples.